Genistin

Product Name: Genistin
CAS No.: 529-59-9
Chemical Name: Genistin
Synonyms: GENISTEIN-7-O-GLUCOSIDE;GENISTEIN-7-GLUCOSIDE;genistein 7-O-β-D-glucoside;GENISTIN;NSC 5112;genistine;Genistoside;Genistin ,98%;GENISTIN >99%;Genistin (30 mg)
CBNumber: CB9769395
Molecular Formula: C21H20O10
Formula Weight: 432.38
MOL File: 529-59-9.mol

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Genistin Property

Melting point:: 254°C
alpha: D21 -28° (c = 0.6 in 0.02N NaOH); D26 -21.4° (pyridine)
Boiling point:: 256 °C
Density: 1.642±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 10 mg/mL
pka: 6.12±0.20(Predicted)
color: Off-white
Merck: 13,4402
BRN: 64479
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
InChIKey: ZCOLJUOHXJRHDI-CMWLGVBASA-N
LogP: 0.790 (est)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: DJ3093000
F: 10
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1288805
Product name: Genistin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 30mg
Price: $1320
Updated: 2024/03/01

Sigma-Aldrich

Product number: 05380590
Product name: Genistin
Purity: primary reference standard
Packaging: 25mg
Price: $555
Updated: 2023/06/20

Alfa Aesar

Product number: J63445
Product name: Genistin, 99+%
Packaging: 100mg
Price: $487
Updated: 2024/03/01

Cayman Chemical

Product number: 14174
Product name: Genistin
Purity: ≥98%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 14174
Product name: Genistin
Purity: ≥98%
Packaging: 10mg
Price: $112
Updated: 2024/03/01

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Genistin Chemical Properties,Usage,Production

Description

Genistin is a natural isoflavone isolated from legumes, including soy and kudzu. It is a phytoestrogen, as it stimulates the growth of estrogen-dependent human breast cancer cells in vivo. Like other isoflavones, genistin promotes the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover. It also increases bone formation in collagen matrix in vivo.

Chemical Properties

White Powder

Uses

A derivative of Genistein. Inhibitor

Uses

An isoflavone glycoside which is an inactive analog of the PTK inhibitor Genistein.

Uses

Genistin has been used for immune reactivity against influenza viruses in vitro and as an internal standard in isoflavones quantification.

Uses

Glucoside of genistein that inhibits protein tyrosine kinase

Definition

ChEBI: Genistein 7-O-beta-D-glucoside is a 7-hydroxyisoflavones 7-O-beta-D-glucoside. It is functionally related to a genistein. It is a conjugate acid of a genistein 7-O-beta-D-glucoside(1-).

General Description

Genistin belongs to the class of isoflavone glycosides generally extracted from soybeans.

Biochem/physiol Actions

Selective inhibitor of mammalian terminal deoxynucleotidyl transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases.

Purification Methods

Genistin is repeatedly crystallised from hot 80% EtOH/water and treated with charcoal (Nuchar) until free from saponin. The presence of saponin is detected by adding crystals to conc H2SO4 when the citron yellow colour changes to red, then purple. Pure genistin does not change colour. UV in 85% EtOH has max at 262.5nm. [Walter J Am Chem Soc 63 3273 1941, Beilstein 18 III/IV 2732.]

References

1) Uchiyama et al. (2005), Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin; Biochim. Biophys. Acta, 1725 298 2) Choi et al. (2007), Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells; Life Sci, 80 1403 3) Russo et al. (2006), Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells; J. Nutr. Biochem., 17 103

Genistin Preparation Products And Raw materials

Raw materials

Preparation Products

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Genistin Suppliers

Canada 1 China 253 Europe 4 France 2 Germany 3 India 6 Japan 3 Switzerland 2 United Kingdom 12 United States 43 Global 329

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View Lastest Price from Genistin manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Genistin 529-59-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: Genistin 529-59-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Genistin 529-59-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

529-59-9, GenistinRelated Search:

Trimethylolpropane Alkyl polyglucoside Tris(hydroxymethyl)aminomethane BETA-GLUCOSIDASE Genistein Bengenin Baicalin Resveratrol Glycitein Taxifolin Isoflavone Tectoridin 6''-O-ACETYLGENISTIN OCTYL GLUCOSIDE kakkalide Genistin GENISTIN SNAP-N-SHOOT 0.1mg/ml(P) GENISTIN(P)

4',5,7-TRIHYDROXYISOFLAVONE 7-GLUCOSIDE

7-O-B-D-GLUCOPRYANOSYL GENISTEIN

7-O-BETA-D-GLUCOPYRANOSIDE

GENISTEIN-7-GLUCOSIDE

GENISTEIN, 7-O-BETA-D-GLUCOPYRANOSIDE

GENISTEIN-7-O-GLUCOSIDE

GENISTIN

GLUCOSYL-7-GENISTEIN

4μ,5,7-Trihydroxyisoflavone 7-glucoside, Genistein 7-glucoside, Genistein-7-O-β-D-glucopyranoside

Genistin，Genistein 7-glucoside

7-[(β-D-Glucopyranosyl)oxy]-4',5-dihydroxyisoflavone

Genistin ,98%

Genistin,4′,5,7-Trihydroxyisoflavone 7-glucoside, Genistein 7-glucoside, Genistein-7-O-β-D-glucopyranoside

Genistin (30 mg)

genistein,7-o-beta-d-glucoside

genistine

7-(-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Genistein-7--O-Glucopyranoside

Genistein-7-O-β-D-glucopyranoside

genistin from glycine max

7-(b-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Genistein-7-b-O-Glucopyranoside

Genistoside

NSC 5112

genistein 7-O-β-D-glucoside

Genistin - CAS 529-59-9 - Calbiochem

5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chroMen-7-ylbeta-D-glucopyranoside

Genistin (Genistoside)

7-(beta-d-glucopyranosyloxy)-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on

genistein,7-beta-d-glucopyranoside

4,5,7-Trigydroxyisoflavone 7-glucoside

Genistin, froM soybean

Genistin 4',5,7-Trihydroxyisoflavone 7-glucoside

Genistein glucoside

5-hydroxy-3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-chromen-4-one

4H-1-Benzopyran-4-one, 7-(.beta.-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-

GENISTIN >99%

GENISTIN WITH HPLC

-5-hydroxy-3-(4-hydroxyphenyl)-

Nano Liposomal Genistin

Genistin, 99%, from soybean

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-

genistein7-O-β-D-glucoside

4',5,7-Trihydroxyisoflavone 7-beta-D-Glucopyranoside

Genistin USP/EP/BP

Genistein-7-O-β-D-glucopyranoside

5-hydroxy-3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

5-Hydroxy-3-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

Genistin Supplier

Genistin (6CI, 7CI, 8CI)

Genistein 7-O-β-D-glucopyranoside, 7-(β-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, NSC 5112

Coumarin Impurity 10 (Coumarin 102)

529-59-9

5529-29-9

C21H20O10

43238

Receptor Tyrosine Kinase Inhibitors

Tyrosine Kinase (TK)